[Young Journalist Sophia Lee] AMOREPACIFIC developed a new peptide that selectively strengthens keratin within hair using artificial intelligence (AI) and molecular modeling and published related research results in the International Journal of Cosmetic Science. 

The hair gets damaged as it is consistently exposed to various external stresses such as ultraviolet rays, heat, and chemical procedures. These damages weaken the protein structure of keratin in the hair, leading to hair breakage and loss of elasticity. To solve the problems, AMOREPACIFIC R&I center has closely analyzed peptide candidates that can selectively bind with hair keratin using the molecular docking and molecular dynamics simulation.

As a result of analyzing approximately 8,000 types of compositions, the researchers discovered the optimal peptide ‘Tripeptide-132’ that has fine cohesion with keratin. The research result showed that the hair treated with this peptide had improved tensile strength up to 44% and reduced the hair breakage in repetitive external stress conditions by around 50%. Also, it has been proven that the peptide elevates the tidiness and lubricity of the hair surface through the cuticle structure analysis. 

This suggests that the peptide radically reinforces the internal structure of the weakened hair and keeps the elastic condition of the hair that does not easily break despite the daily hair drying and styling processes. It raises expectations to improve the sensible user experience at the same time, such as the smoothness of the hair that can be felt through hands by cuticle tidying. The research is meaningful as it precisely identified the hair improvements mechanism by ‘molecular design-keratin binding-strengthening hair structure-elevated sense of use’; scientifically explaining the burnish and smoothness of hair.

AMOREPACIFIC R&I center has continued the research that understands and integrates the structure and function of skin·scalp·hair at the molecular level, based on the biotech prowess built up from skin barrier, microbiome, and aging research. This scientific basis is being amplified to scalp and hair, beyond skin care, that secures competitiveness in the high functioning material design and efficacy verification. Based on this foundation, AMOREPACIFIC strengthens the beauty research by the perspective of ‘holistic longevity’. To implement healthy beauty throughout the lifespan, it is advancing the research based on precision targeting competency with the background of radical understanding of aging and damage, also in the  realm of hair·scalp. 

The AMOREPACIFIC R&I center director Byeong-Hwee Seo stated that “this study is the revolutionary case that precisely targeted the hair protein with AI and molecular design technology” and “AMOREPACIFIC is going to build up the competitiveness in hair beauty based on the AI First strategy and Holistic Longevity perspective. 

Besides, the finding of this research has been applied to Peptide-132 shampoo, hair conditioner, hair bonding oil, launched by COSRX, where they are being used as a solution for damaged hair care.AMOREPACIFIC Develops a Hair Keratin Strengthening Peptide Based on AI・Molecular Modeling

AMOREPACIFIC developed a new peptide that selectively strengthens keratin within hair using artificial intelligence (AI) and molecular modeling and published related research results in the International Journal of Cosmetic Science. 

The hair gets damaged as it is consistently exposed to various external stresses such as ultraviolet rays, heat, and chemical procedures. These damages weaken the protein structure of keratin in the hair, leading to hair breakage and loss of elasticity. To solve the problems, AMOREPACIFIC R&I center has closely analyzed peptide candidates that can selectively bind with hair keratin using the molecular docking and molecular dynamics simulation.

As a result of analyzing approximately 8,000 types of compositions, the researchers discovered the optimal peptide ‘Tripeptide-132’ that has fine cohesion with keratin. The research result showed that the hair treated with this peptide had improved tensile strength up to 44% and reduced the hair breakage in repetitive external stress conditions by around 50%. Also, it has been proven that the peptide elevates the tidiness and lubricity of the hair surface through the cuticle structure analysis. 

This suggests that the peptide radically reinforces the internal structure of the weakened hair and keeps the elastic condition of the hair that does not easily break despite the daily hair drying and styling processes. It raises expectations to improve the sensible user experience at the same time, such as the smoothness of the hair that can be felt through hands by cuticle tidying. The research is meaningful as it precisely identified the hair improvements mechanism by ‘molecular design-keratin binding-strengthening hair structure-elevated sense of use’; scientifically explaining the burnish and smoothness of hair.

AMOREPACIFIC R&I center has continued the research that understands and integrates the structure and function of skin·scalp·hair at the molecular level, based on the biotech prowess built up from skin barrier, microbiome, and aging research. This scientific basis is being amplified to scalp and hair, beyond skin care, that secures competitiveness in the high functioning material design and efficacy verification. Based on this foundation, AMOREPACIFIC strengthens the beauty research by the perspective of ‘holistic longevity’. To implement healthy beauty throughout the lifespan, it is advancing the research based on precision targeting competency with the background of radical understanding of aging and damage, also in the  realm of hair·scalp. 

The AMOREPACIFIC R&I center director Byeong-Hwee Seo stated that “this study is the revolutionary case that precisely targeted the hair protein with AI and molecular design technology” and “AMOREPACIFIC is going to build up the competitiveness in hair beauty based on the AI First strategy and Holistic Longevity perspective. 

Besides, the finding of this research has been applied to Peptide-132 shampoo, hair conditioner, hair bonding oil, launched by COSRX, where they are being used as a solution for damaged hair care.

▶원문 기사: 아모레퍼시픽 AI·분자모델링 기반 모발 케라틴 강화 펩타이드 개발
 

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